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Evaluation of Remineralization Effects on Enamel Demineralization by Anti-cariogenic Agents using Quantitative Light-induced Fluorescence-digital (QLF-D) in vitro

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Abstract

º» ¿¬±¸ÀÇ ¸ñÀûÀº quantitative light-induced fluorescence-digital(QLF-D) ½Ã½ºÅÛÀ» ÀÌ¿ëÇÏ¿© À¯Ä¡¿Í ¿µ±¸Ä¡¿¡ Çü¼ºµÈ ŻȸµÈ ¹ý¶ûÁú¿¡ ¼­·Î ´Ù¸¥ ¼¼ Á¾·ùÀÇ Ç׿ì½Ä Á¦Ç° Àû¿ë ÈÄ °¢°¢ÀÇ À籤ȭ È¿°ú¸¦ ºñ±³ÇÏ´Â µ¥ ÀÖ´Ù. ¿¬±¸¸¦ À§ÇØ °¢ 48°³ÀÇ °ÇÀüÇÑ À¯Ä¡ ¹× ¿µ±¸Ä¡¸¦ ´ë»óÀ¸·Î ´ëÁ¶±º(1±º), ºÒ¼Ò ÇÔÀ¯ Ä¡¾à(2±º), functionalized tricalcium phosphate(fTCP) + ºÒ¼Ò ÇÔÀ¯ Ä¡¾à(3±º), casein phosphopeptide-amorphous calcium phosphate(CPP-ACP) ÇÔÀ¯ Ä¡¾Æ Å©¸²(4±º)À¸·Î ¹«ÀÛÀ§ ºÐ·ùÇÏ¿´´Ù. À¯Ä¡ ¹× ¿µ±¸Ä¡¿¡ ¹ý¶ûÁú Żȸ¸¦ À¯¹ßÇÑ ÈÄ, 14ÀÏ µ¿¾È 1ÀÏ 2ȸ Ç׿ì½Ä Á¦Ç°À» ó¸®ÇÏ¿´À¸¸ç, quantitative light-induced fluorescence(QLF)¸¦ ÀÌ¿ëÇÏ¿© À籤ȭ È¿°ú¸¦ ºñ±³ ºÐ¼®ÇÏ¿´´Ù. ¿¬±¸ °á°ú, ¼¼ Á¾·ùÀÇ Ç׿ì½Ä Á¦Ç° ¸ðµÎ À¯Ä¡¿Í ¿µ±¸Ä¡¿¡¼­ ´ëÁ¶±ºÀÎ 1±º¿¡ ºñÇØ ¿ì½Ä º´¼ÒÀÇ ¹«±âÁú ¼Ò½Ç·®À» À¯ÀÇÇÏ°Ô °¨¼Ò½ÃÄ×À¸¸ç, Ä¡¾à Á¦Ç° °£ ºñ±³¿¡¼­´Â 3±º°ú 4±º¿¡¼­ 2±º¿¡ ºñÇØ À¯ÀÇÇÏ°Ô ³ôÀº À籤ȭ È¿°ú¸¦ ³ªÅ¸³Â´Ù. À̸¦ ÅëÇÏ¿© fTCP¿Í ºÒ¼Ò ÇÔÀ¯ Ä¡¾à ¹× CPP-ACP ÇÔÀ¯Ä¡¾Æ Å©¸²ÀÌ À¯Ä¡¿Í ¿µ±¸Ä¡ ¸ðµÎ¿¡¼­ ¿ì¼öÇÑ À籤ȭ È¿°ú¸¦ º¸Àδٴ °Í°ú, QLF-D°¡ Ãʱ⠿ì½Ä º´¼Ò¿Í Ç׿ì½Ä Á¦Á¦ÀÇ À籤ȭ È¿°ú¸¦ Á¤·®ÀûÀ¸·Î Æò°¡ÇÔ¿¡ ÀÖ¾î À¯¿ëÇÑ ÀåºñÀÓÀ» ¾Ë ¼ö ÀÖ´Ù. ±×·¯¹Ç·Î ÀÓ»ó°¡µéÀº À¯Ä¡¿Í ¿µ±¸Ä¡¿¡¼­ÀÇ Å»È¸ ¹× À籤ȭ Æò°¡ ½Ã QLF-D ½Ã½ºÅÛÀÇ ÀÓ»óÀû Àû¿ëÀ» °í·ÁÇÒ ¼ö ÀÖÀ» °ÍÀÌ´Ù.

The purpose of this study was to evaluate the difference of remineralization effects of various anti-cariogenic toothpastes on artificial carious lesions in primary and permanent teeth using quantitative light-induced fluorescence-digital (QLF-D) system. Sound human primary (n = 48) and permanent teeth (n = 48) were randomly divided into following groups : control group (Group 1), fluoride toothpaste (Group 2), functionalized tricalcium phosphate (fTCP) + fluoride toothpaste (Group 3), and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) toothpaste (Group 4). Specimens were prepared by exposure in a demineralizing solution and then treated using the different toothpastes twice daily during 14 days. All specimens were analyzed with the QLF-D system. QLF data analysis indicated three different toothpastes showed significant remineralizing effects compared to Group 1 in both primary and permanent teeth. Also, the remineralizing effects in Group 3 and 4 were significantly higher than in Group 2. This study suggested that the toothpastes containing fTCP + fluoride and CPP-ACP have the significant anti-cariogenic effects on enamel demineralization in both primary and permanent teeth, and QLF-D is an useful device to assess the incipient carious lesion and remineralization effects of the anti-cariogenic materials quantitatively. Therefore, clinicians can consider the QLF-D system for the evaluation of demineralization and remineralization in primary and permanent teeth.

Å°¿öµå

Á¤·® ±¤ À¯µµ Çü±¤¹ý ; Ä¡¾Æ À籤ȭ ; Ä¡¾à ; ¹é»ö ¹ÝÁ¡
Quantitative light-induced fluorescence ; Tooth remineralization ; Toothpastes ; White spot

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